2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N13241
    Rhodiola Rosea Extract 98%
    Rhodiola Rosea Extract is a rhodiola rosea extract, and its components include: Salidroside. Rhodiola Rosea Extract can affect the release of stress hormones, promote energy metabolism, and can be used in the study of "stress" indications..
    Rhodiola Rosea Extract
  • HY-N13285
    (-)-Epigallocatechin-4'-O-methylether 17291-05-3 98%
    (-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury.
    (-)-Epigallocatechin-4'-O-methylether
  • HY-N13380
    6′‐O‐Galloylsalidroside 83013-86-9 98%
    6’-O-Galloylsalidroside is an active component of Rhodiola. 6’-O-Galloylsalidroside is promising for research of Alzheimer’s disease, lung diseases, cerebrovascular disease, diabetes, cardiovascular disease and aging-related diseases.
    6′‐O‐Galloylsalidroside
  • HY-N1377R
    Nevadensin (Standard) 10176-66-6 98%
    Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.
    Nevadensin (Standard)
  • HY-N1382R
    Asperuloside (Standard) 14259-45-1 98%
    Asperuloside (Standard) is the analytical standard of Asperuloside. This product is intended for research and analytical applications. Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways.
    Asperuloside (Standard)
  • HY-N1390R
    Syringaldehyde (Standard) 134-96-3
    Syringaldehyde (Standard) is the analytical standard of Syringaldehyde. This product is intended for research and analytical applications. Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.
    Syringaldehyde (Standard)
  • HY-N1411R
    Platycodin D (Standard) 58479-68-8
    Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D.
    Platycodin D (Standard)
  • HY-N14186
    Asperaldin 561297-46-9 98%
    Asperaldin is a potent aldose reductase (RLAR) inhibitor found in Aspergillus niger CFR-1046.
    Asperaldin
  • HY-N1425R
    Tiliroside (Standard) 20316-62-5
    Tiliroside (Standard) is the analytical standard of Tiliroside. This product is intended for research and analytical applications. Tiliroside, a glycosidic flavonoid, possesses anti-diabetic activities. Tiliroside is a noncompetitive inhibitor of α-amylase with a Ki value of 84.2 μM. Tiliroside inhibits carbohydrate digestion and glucose absorption in the gastrointestinal tract.
    Tiliroside (Standard)
  • HY-N1427R
    Glycodeoxycholate Sodium (Standard) 16409-34-0
    Glycodeoxycholate (Sodium) (Standard) is the analytical standard of Glycodeoxycholate (Sodium). This product is intended for research and analytical applications. Glycodeoxycholate Sodium (Sodium glycyldeoxycholate) is a bile salt. Glycodeoxycholate Sodium has cytotoxicity to cancer cell, changes the permeability of the pancreatic duct and decreases glucose levels[1][2][3].
    Glycodeoxycholate Sodium (Standard)
  • HY-N1435R
    Oroxin B (Standard) 114482-86-9 98%
    Oroxin B (Standard) is the analytical standard of Oroxin B. This product is intended for research and analytical applications. Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT. Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells.
    Oroxin B (Standard)
  • HY-N1444R
    Complanatuside (Standard) 116183-66-5
    Complanatuside (Standard) is the analytical standard of Complanatuside. This product is intended for research and analytical applications. Complanatuside is a flavonoid found in the traditional Chinese medicine Semen Astragali Complanati.
    Complanatuside (Standard)
  • HY-N1446R
    Oleic acid (Standard) 112-80-1 98%
    Oleic acid (Standard) is the analytical standard of Oleic acid. This product is intended for research and analytical applications. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.
    Oleic acid (Standard)
  • HY-N1458R
    Isoschaftoside (Standard) 52012-29-0
    Isoschaftoside (Standard) is the analytical standard of Isoschaftoside. This product is intended for research and analytical applications. Isoschaftoside, a C-glycosylflavonoid from Desmodium uncinatum root exudate, can inhibit growth of germinated S. hermonthica radicles. Isoschaftoside reduces reactive oxygen species (ROS) and induces proliferation in senescent cells. Isoschaftoside activates autophagy. Isoschaftoside can be used for anti-tumor, anti-inflammatory, antioxidant, antihypertensive, hepatoprotective and nematicidal study.
    Isoschaftoside (Standard)
  • HY-N1462R
    Atractyloside potassium salt (Standard) 102130-43-8
    Atractyloside (potassium salt) (Standard) is the analytical standard of Atractyloside (potassium salt). This product is intended for use in research and analytical applications. Atractyloside potassium salt is a powerful and specific inhibitor of mitochondrial ADP/ATP transport. Atractyloside potassium salt inhibits chloride channels from mitochondrial membranes of rat heart. Atractyloside potassium salt activates autophagy, inhibits ANT2, mTOR and promotes the activation of p-AMPK. Atractyloside potassium salt has anti-cancer effects on non-small cell lung cancer and can inhibit liver steatosis. Atractylodesin potassium salt has nephrotoxicity.
    Atractyloside potassium salt (Standard)
  • HY-N1470R
    Plantagoside (Standard) 78708-33-5
    Plantagoside (Standard) is the analytical standard of Plantagoside (HY-N1470). This product is intended for research and analytical applications. Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC50 values of 5 μM and a Ki of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes.
    Plantagoside (Standard)
  • HY-N15152
    Isoaesculioside D 1184581-59-6 98%
    Isoaesculioside D (compound 3) is an agent for preventing or ameliorating skin aging. Isoaesculioside D exhibits an excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin.
    Isoaesculioside D
  • HY-N15196
    Andrographolide-lipoic acid 1167601-06-0 98%
    Andrographolide-lipoic acid is an Andrographolide (HY-N0191) analogue, which is formed by the coupling of Andrographolide and Lipoic acid (HY-18733). Andrographolide-lipoic acid inhibits NF-κB and has anti-diabetic and β-cell protective activities.
    Andrographolide-lipoic acid
  • HY-N15216
    Ganolucidic acid B 98683-75-1 98%
    Ganolucidic acid B is a triterpenoid compound found in Ganoderma sinense. Ganolucidic acid B can activate hPXR-mediated CYP3A4 expression. Ganolucidic acid B can be used in metabolism-related research.
    Ganolucidic acid B
  • HY-N15229
    Resinacein L 2259327-01-8 98%
    Resinacein L is an inhibitor for α-glucosidase with an IC50 of 0.635 mM. Resinacein L slows down the digestion and absorption of carbohydrates, thereby decreasing postprandial blood glucose.
    Resinacein L
Cat. No. Product Name / Synonyms Application Reactivity